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Doctor Gross makes her first appearance in "Preboot." She creates hybrids of organisms, presumably her work is the opposite of extinction.
Doctor Gross, outside of her suit, is a tan-skinned human. She has teal colored hair. Due to her extensive modifications, she is extremely mechanized with features including: spider-like legs and the ability to change her body into the weapon of her choice (such as making her arm into 3 rotating saw blades and making her hand into scissor hands). She is also able to send signals through a monocle she activates.
Upon observing Susan's head implant, she seems intrigued, then surprised as she reads its serial number. After her defeat, Gross offers to tell Susan everything, but the giantess flees without listening.
- Her methods for wanting to help upgrade involuntary lifeforms through cybernetics make her similar to The Borg Queen from Star Trek, The Next Generation.